Publications

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2021

 

Cho, C., Deol, H., Martin, LJ. 2021. Bridging the translational divide in pain research: Biological, psychological and social considerations. Front Pharmacol. (In Press). 

Cho, C., Chan, C., Martin, LJ. 2021. Can Male Mice Develop Preference Towards Gentle Stroking by an Experimenter? Neurosci (In Press)

 

2020

 

Zhang, H., Lecker, I., Collymore, C., Dokova, A., Phamm, MC., Rosen, SF., Crawhall-Duk, H., D’Souza, AJ., Cho, C., Michailidis, V., Steenland, HW., Lee, WV., Moayedi, M., Sterley, TL., Bains, J., Stratton, JA., Matyas, JR., Biernaskie, J., Dubins, D., Vukobradovic, I., Bezginov, A., Fleeniken, AM., Martin, LJ., Mogil, JS., Bonin, RP. Hanging Behavior as a clinically relevant measure of pain in mice. Pain. (In Press).

Darvish-Ghane, S., Quintana, C., Beaulieu, JM., Martin, LJ. 2020. D1 receptors in the anterior cingulate cortex modulate basal mechanical sensitivity threshold and glutamatergic synaptic transmission Mol. Brain. 13:121.

 

Ramzan, F., Creighton, SD., Hall, M., Baumbach, J., Wahdan, M., Poulson, SJ., Michailidis, V., Stefanelli, G., Narkaj, K., Tao, CS., Khan, D., Steininger Jr., C., Walters, BJ., Monks, DA., Martin, LJ., Zovkic, IB. 2020. Sex-specific effects of the histone variant H2A.Z on fear memory, stress-enhanced fear learning and hypersensitivity to pain. Sci. Rep. Aug 31;10(1):14331.

 

Poulson, SJ., Aldarraji, A., Arain, I., Motlana, K., Dziekonski, N., Riley, R., Holmes, MM., Martin, LJ. 2020. Naked mole-rats lack cold sensitivity after nerve-injury. 2020. Mol Pain. 16:1744806920955103

Poulson, SJ., Martin, LJ. 2020. Social communication and modulation of pain. In: Dynamics of pain. Eds. Robert Sorge. Great River Learning. Dubuque IA.

The dichotomous role of epiregulin in pain. Verma, V., Khoury, S., Parisien, M., Cho, C., Maixner, W., Martin, LJ*., Diatchenko, L.*  2019. Pain. May;161(5)1052-1064. *Co-senior authors. [Impact Factor = 5.56].  

2019

The role of hedonics in the human affectome. Becker, S., Bräscher, AK., Bannister, S., Bensafi, M., Calma-Birling, D., Chan, R., Eerola, T., Ellingsen, DM., Ferdenzi, C., Hanson, J., Joffily, M., Lidhar, N., Lowe, L., Martin, LJ., Musser, E., Noll-Hussong, M., Olino, T., Pintos Lobo, R., Wang, Y. 2019.  Neurosci Biobehav Rev. July;102:221-241. [Impact Factor = 9.440].

Evaluating analgesic efficacy and administration route following craniotomy in mice using the grimace scale. Cho, C., Michalidis, V., Lecker, I., Collymore, CV., Loka, M., Danesh, M., Bonin, RP., Martin, LJ. 2019. Sci Rep. Jan 23;9(1):359. [Impact Factor = 5.56; posted on BioRxiv]

 

Male-specific conditioned pain hypersensitivity in mice and people. Martin, LJ. Acland, EL., Cho, C., Gandhi, W., Chen, D., Corley, E., Kadoura, B., Levy, T., Mirali, S., Tohyama, S., Khan, S., MacIntyre, L., Carlson, EN., Schweinhardt, P., Mogil, J. 2019. Curr Biol. Jan 21;29(2):192-201. [Impact Factor = 9.97]​.

Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity. Tansley, S., MacIntyre, L., Diamond, L., Sotocinal, S., George, N., Austin, JS., Coderre, T., Martin, LJ*., Mogil, JS*. 2019. Pain.  Apr;160(4):784-792. *Co-corresponding authors. [Impact Factor = 5.56].

 

Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain. Parisien, M., Samoshkin, Tansley, SN., Piltonen, MH., Martin, LJ., El-Hachem, N., Dagostino, C., Allegri, M., Mogil, JS., Khoutorsky, A., Diatchenko, L. 2019. Pain. Apr;160(4):932-944 [Impact Factor = 5.56]

 

2018

Mechanistic and Behavioral Insight into Rodent Empathy. Sivaselvachandran, S., Acland, EL., Abdallah, S.,Martin, LJ. 2016.  Neurosci Biobehav Rev. 2018 August 2018, 91: 130-137 [Impact Factor = 9.440].

 

All or none or matter of degree? Martin, LJ., Gerlai, R. Sentience: Animal Sentience. 2018. 3 (21), 9.

Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain. Cho, C, Michailidis, V., Martin, LJ.  Neurobiol 2018. Pain.Aug-Dec;4:27-34.[Impact Factor = 3.596] doi.org/10.1016/j.ynpai.2018.03.002.

 

2017

Epiregulin and EGFR interactions are involved in pain processing. Martin, LJ., Smith, SB., Khoutorsky, A., Magnuson, C., Samoshkin, A., Sorge, RE., Cho, C., Yosefpour , N., Sivaselvachandran, S., Tohyama, S., Cole, T., Khuong, TM., Mir,, E., Gibson, DG., Wieskopf, JS., Sotocinal, SG., Austin, JS., Meloto, C., Gitt, JH., Sonenberg, N., Greenspan, JD., Fillingim, RB., Ohrbach, R., Slade, GD., Knott, C., Dubner, R., Nackley, AG., Ribeiro-da-Silva, A., Maixner, W., Zaykin, DV., Mogil1, JS., Diatchenko, L.  J Clin Inves. 2017. Sep 1;127(9):3353-3366. [Impact Factor = 12.784]

 

Social propinquity in Rodents as Measured by Tube Co-occupancy Differs Between Inbred and Outbred Genotypes. Tuttle, AH., Tansley, S., Dossett, K., Tohyama, S., Khourtorsky, A., Maldonado-Bouchard, S., Stein, L., Gerstein, L., Crawhall-Duk, H., Pearl, R., Sukosd, M., Leger, P., Hardt, O., Yachnin, D., Austin, JS., Chan, CM., Groves, I, Pooters, T., Sonenberg, N., Martin, LJ., Gkogkas, CG., Mogil, JS. Proc Natl Acad Sci U S A. , 2017. May 23; 114(21):5515-5520. [Impact Factor = 9.423].

 

2016

eIF2α phosphorylation controls thermal nociception. Khoutorsky, A., Sorge, RE., Prager-Khoutorsky, M., Pawlowski, SA., Longo, G., Mehdi Jafarnejad, S., Tahmasebi, Martin, LJ.,Pitcher, M., Gkogkas, CG., Sharif-Naeini, R., Riveiro-da-Silva, A., Bourque, CW., Cervero, F., Mogil, JS., Sonenberg, N.   Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11949-11954. [Impact Factor = 9.423].

 

The Use of DREADDs to Deconstruct Behavior. Whissell, PD., Tohyama, S., Martin, LJ. Front Genet. 2016 May 17;7:70. doi: 10.3389/fgene.2016.00070. eCollection 2016. 

 

2015

Differential efficacy of the non-selective beta-adrenergic antagonist bupranolol for treatment against neuropathic and inflammatory pain. Martin, LJ., Piltonen, MH., Gauthier, J., Convertino, M., Acland, EA., Dokholyan, NV., Mogil, JS., Diatchenko, L., Maixner, W. J Pain 2015 Dec;16(12):1321-33.

 

Translational control of nociception via 4E-binding protein 1. Khoutorsky, A., Bonin, RP., Sorge, RE., Gkogkas, CG., Pawlowski, SA., Jafarnejad, SM., Pitcher, MH., Alain, T., Perez-Sanchez, J., Salter, EW., Martin, LJ., Ribeiro-da-Silva, A., De Koninck, Y., Cervero, F., Mogil,JS., Sonenberg, N. Elife 2015. Dec 18;4. pii: e12002. [Impact Factor = 9.32]

Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Sorge, RE., Mapplebeck JC., Rosen, S., Beggs, S., Taves, S., Alexander, JK., Martin,LJ., Austin, JS., Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS. Nat Neurosci. 2015 Aug;18(8):1081-3. [Impact Factor = 16.095]

 

Molecular genetic mechanisms of allelic specific regulation of murine Comt expression. Segall SK, Shabalina SA, Meloto CB, Wen X, Cunningham D, Tarantino LM, Wiltshire T, Gauthier J, Tohyama, S., Martin,LJ., Mogil,JS., Diatchenko, L.  Pain. 2015 Oct;156(10):1965-77 [Impact Factor = 5.84]

 

The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. Wieskopf, JS., Mathur, J., Limapichat, W., Post, MR., Al-Qazzaz, M., Sorge, RE., Martin,LJ., Zaykin, DV., Smith, SB., Freitas, K., Austin, JS., Dai, F., Zhang, J., Marcovitz, J., Tuttle, AH., Slepian, PM., Clarke, S., Drenan, RM., Janes, J., Al Sharari, S., Segall, SK., Aasvang, EK., Lai, W., Bittner, R., Richards, CI., Slade, GD., Kehlet, H., Walker, J., Maskos, U., Changeux, JP., Devor, M., Maixner, W., Diatchenko, L., Belfer, I., Dougherty, DA., Su, AI., Lummis, SC., Imad Damaj, M., Lester, HA., Patapoutian, A., Mogil, JS. Sci Transl Med. 2015 May 13;7(287):287ra72. [Impact Factor = 14.41]

 

Elicitation of empathy for pain in strangers by social stress reduction in mice and humans. Martin, LJ., Hathaway, GA., Isbester, K., Mirali, S., Acland, EL., Niederstrasser, N., Slepian, P., Trost, Z., Bartz, JL., Sternberg, W., Sapolsky, R., Levitin, D., Mogil, JS.  Curr Biol. 2015 Feb;25(3):326-32. [Impact Factor = 9.97]

 

2014

Stress-induced analgesia in the mouse via cross species olfactory exposure to human males. Sorge, RE*., Martin, LJ*., Isbester, KA., Sotocinal, SG., Rosen, S., Tuttle, AH., Wieskopf, JS., Acland, EL., Dokova, A., Kadoura, B., Leger, P., Mapplebeck, JCS., McPhail, M., Delaney, A., Wigerblad, G., Schumann, AP., Quinn, T., Frasneli, J., Svensson, CI., Sternberg, W., Mogil, JS.  Nat Methods 2014 Jun;11(6):629-32.*equal contributions[Impact Factor = 25.953]

 

2013

Acutely increasing δGABAAreceptor activity causes memory deficits and inhibits synaptic plasticity in the hippocampus. Whissell, PD., Eng, D., Lecker, I., Martin, LJ.,Wang, DS., Orser, BA. Front Neural Circuits. 2013 Sept;17(7):146

 

2011

The rat grimace scale: A partially automated method for quantifying pain in the laboratory rat via facial expressions. Sotocinal, SG., Sorge, RE., Zaloum, A., Tuttle, AH., Martin, LJ.,Wieskopf, JS., Mapplebeck, JCS., Wei, P., Zhan, S., Zhang, S., Mcdougall, JJ., King, OD., Mogil, JS.  Mol Pain. 2011 Jul;7:55. 

 

The sedative but not the memory-blocking properties of ethanol are modulated by α5-subunit-containing γ-aminobutyric acid type A receptors. Martin, LJ., Zurek, AA., Bonin, RP., Kim, J., Mount, HTJ., Orser, BA. Behav Brain Res. 2011 Mar;17(2):379-85. 

 

2010

α5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory. Martin, LJ., Zurek, AA., Macdonald, JF., Roder, JC., Jackson, MF., Orser, BA. .J Neurosci. 2010 Apr;30(15):5269-82.[Impact Factor = 7.12]

 

Schaffer collateral activation of a5 subunit-containing GABAA receptors mediates a slowly decaying synaptic current in CA1 pyramidal neurons. Vargas-Caballero, M., Martin, LJ., Salter, MW., Orser, BA., Paulsen, O.  Neuropharm 2010 Mar;58(3):668-75. [Impact Factor 5.106]

 

Pretreatment with the α5GABAA receptor inverse agonist, L-665,708 prevents persistent memory impairment after isoflurane. Saab, BJ., Maclean, AJB., Kanisek, M., Martin, LJ., Zurek, AA., Roder, JC., Orser., BA. .Anesthesiology 2010 Nov;113(5):1061-1071. [Impact Factor 6.168]

 

Cerebral neurons in Rattus norvegicus following a mild impact to the skull: equivalence of modulation by post-impact pregnancy or exposure to physiologically-patterned magnetic fields. Cheung, KW., Lado, WE., Martin, LJ., St-Pierre, LS., Persinger, MA..  Journal of Biological Sciences. 2010 10(2):84-92.

 

2009

Etomidate Targets a5GABAAreceptors to regulate synaptic plasticity and memory blockade. Martin, LJ., Oh, GHT., Orser, BA.  Anesthesiology 2009 Nov;111(5):1025-3. [Impact Factor 6.168]

 

Suppression of hippocampal TRPM7 enhances neuronal survival, function and learning following cerebral ischemia. Sun, HS., Jackson, MF., Martin, LJ., Jansen, K., Teves, L., Cui, H., Mori, Y., Jones, M., Forder, JP., Golde, TE., Orser, BA., MacDonald, JF., Tymianski, M. . Nat Neurosci. 2009 Oct;12(10):1300-7. [Impact Factor = 14.976]

 

The physiological and therapeutic potential of α5GABAA receptors. Martin, LJ., Bonin, RP., Orser., BA. Biochem Soc Trans. 2009 Dec;37(Pt 6):1334-7.

 

2007

α5GABAAreceptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons. Bonin, RP., Martin, LJ., MacDonald, JF., Orser. BA.  J Neurophys. 2007 Oct;98(4):2244-54.

 

2006

α5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic, etomidate. Cheng, VY*., Martin, LJ*., Elliot, EM., Kim,J., Mount, HT., Taverna, FA., Roder, JC., MacDonald, JF., Bhambri, A., Collinson, N., Wafford, KA., Orser,  BA.  J Neurosci. 2006 Apr;26(14):3713-20.  *equal contributions[Impact Factor = 7.12]

 

Role of extrasynaptic GABAA receptor in the hippocampus. Orser, BA., Martin, LJ., Cheng, VY., Bonin. RP. Eur Neuropsychopharm. 2006 Jan;16(S4), S198-99.

 

2005

Modulation of N-methyl-D-aspartate receptors by Pituitary Adenylate Cyclase Activating Peptide in CA1 Neurons Requires Gaq, PKC and Activation of Src. Macdonald, DS., Weerapura, M, Beazely, MA, Martin, LJ, Czerwinski, W, Roder JC., Orser, BA., MacDonald, JF.  J Neurosci. 2005 Dec;25(49):11374-84. [Impact Factor = 7.12]

 

Thermal analgesic effects from weak (1 mT), complex magnetic fields: Critical Parameters. Martin, LJ., Koren, SA., Persinger, MA.  Elect Bio Med. 2005 24(2):65-85.

 

The influence of various pharmacological agents on the analgesia induced by an applied complex magnetic field treatment in the rat: A receptor system potpourri. Martin, LJ., Persinger, MA. Elect Bio Med. 2005 24(2):87-97.

 

2004

Influence of a complex magnetic field treatment on thermal nociceptive thresholds: The importance of polarity and timing. Martin, LJ., Koren, SA., Persinger, MA.Int J Neurosc. 2004 i114(10):1259-76.

 

Thermal analgesic effects from Weak, complex magnetic fields and pharmacological interactions. Martin, LJ., Koren, SA., Persinger MA. Pharmacol Biochem Behav. 2004 78(2):217-27.

 

Thermal analgesia induced by 30 minutes of exposure to 1 mT burst-firing magnetic fields is strongly enhanced in a dose-dependent manner by the a2 agonist clonidine in rats. Martin, LJ., Persinger, MA..  Neurosci Lett. 2004 366(2):226-9.

 

Chronic administration of the L-type calcium channel blocker nimodipine can facilitate the acquisition of sequence learning in a radial arm maze. Martin, LJ., Fournier, NM., Galic, MA., Emond, MH. Behav Pharmacol. 2004 15(2):133-9.

 

A brief 10-minute exposure to a swim stress augments seizure onset in male rats treated with lithium and pilocarpine. Galic, MA., Fournier, NM., Martin, LJ. Pharm Biochem Behav. 2004 79(2):309-16.

 

2003

Spatial heterogeneity not homogeneity of intensity during exposures to a complex frequency-modulated mT magnetic field facilitates analgesia. Martin, LJ., Persinger MA.Percept Mot Skills. 2003  96:1005-12.

 

2002

Learning and memory in agmatine-treated rats. McKay, BE., Lado, WE., Martin, LJ., Galic, MA., Fournier, NM. Pharmacol Biochem Behav. 2002 72:551-7.